Google+ Facebook Twitter Twitter

Breast cancer cells’ self-sacrifice is potential cause of relapse

For patients with early-stage breast cancer, there is a 7% to 11% chance of relapse within five years after receiving initial treatment.

breast cancer cells - CREDIT - Science Photo Library-c0559159

While chemotherapy aims to eliminate all cancer cells, some of them may evade treatment and survive, resulting in recurrence of the cancer.

In a study that spanned over 10 years, Research Assistant Professor Leong Sai Mun from the National University of Singapore Centre for Cancer Research and his research team sought to uncover the reasons for why some breast cancer tumours survive chemotherapy.

In examining tumour and blood samples from 63 patients with breast cancer across different stages, as well as lab-grown breast cancer cells and laboratory models, the team found that cancer cells with high expression of the small non-coding RNA miR-125b cooperate with surrounding cancer cells to allow the latter to grow and resist chemotherapy.

Contrary to the belief that cancer cells are self-serving and driven by survival, this breakthrough study indicates that they display altruistic behaviour to help other cancer cells thrive by sacrificing their own abilities to multiply.

The authors claim that reveals that disrupting such cooperation could be key to developing more effective treatments.

Leong said: “Our research has identified these cooperative behaviours between cancer cells, which treatment must target specifically for them to be destroyed more effectively. ”

Image credit | Science Photo Library

Related Articles

Chromosomes with telomeres - CREDIT-SPlibrary

Telomere findings may offer insights

A new study shows that an enzyme called PARP1 is involved in repair of telomeres – the lengths of DNA that protect the tips of chromosomes – and that impairing this process can lead to telomere shortening and genomic instability that can cause cancer.

Viral respiratory infection, illustration-CREDIT-science photo library C0553686

Beyond SARS-COV-2

Dr Jennifer Cane, a Postdoctoral Research Assistant, asks what sequencing respiratory viruses can tell us.


Microsatellite instability cancer tests

New US research compares the data of newly diagnosed cancer patients who received two different types of tests to determine their course of treatment.

mri examination-CREDIT-istock-1140748315

Novel genetic variants associated with Alzheimer’s disease

New research has identified several genetic variants that may influence Alzheimer’s disease risk, putting researchers one step closer to uncovering biological pathways to target for future treatment and prevention.