News

AddToAny

Google+ Facebook Twitter Twitter

New test predicts sepsis before blood clots

A new test predicted sepsis soon after infection in mice – well before blood clotting and organ failure – enabling early treatment and increasing survival.

The findings provide a platform to develop rapid and easy-to-perform clinical tests for early sepsis detection and clinical intervention in human patients.

The research team succeeded in detecting a catastrophic shift in blood protein abundance soon after infection that can predict sepsis well before disease symptoms and organ damage arise.

Project lead Professor Michael Mahan, said:  “The key finding was identifying proteins in the blood that arise very soon after infection.”

To carry out the test, a small amount of blood was collected and analysed for an increase in coagulation proteins that are induced but inactive at early stages of infection. Such detection enabled early antibiotic treatment – before activated coagulation proteins induced blood clotting – resulting in markedly increased survival in mice. The technology is open source and freely accessible to all.

The study also demonstrated that antibiotics are less effective after blood proteins increase in response to infection.

Failure may be due to host injury triggered by excessive blood clotting, providing insight into why delays in antibiotic treatment in human sepsis are associated with increased risk of death.

bit.ly/3iQLwS6

Image credit | Shutterstock

Related Articles

web_blood-testing_credit_istock-1384651794.png

SPONSORED: The power of automated gel-based ID-cards in routine immunohematology workflows

Immuno-haematology assays are pivotal to the carrying out of blood grouping, antibody screening and transfusions, and represent a critically time-dependent stage in the patient management pathway.

Technician holding a blood sample ready for testing with other human medical samples in the background.-Image credit - Science-Photo-Library-f0243823

Machine learning tool to detect cancer via liquid biopsy

US researchers have developed and tested an innovative machine-learning approach that could one day enable the earlier detection of cancer in patients by using smaller blood draws.

multiple myelomatosis-CREDIT-Science Photo Library-m132099

IBMS research grants

We look at the work of Dr Mosavar Farahani who received an IBMS Research Grant in 2023 to help fund her work on disease progression and skeletal complications in multiple myeloma.

Jaxon Moran and Emily Jones

My Lab: Flow cytometry laboratory

Jaxon Moran and Emily Jones give a guided tour of the Flow Cytometry Laboratory at Newcastle upon Tyne Hospitals NHS Foundation Trust.

Top