Molecular Pathology & Genomics

Beyond SARS-COV-2

Dr Jennifer Cane, a Postdoctoral Research Assistant, asks what sequencing respiratory viruses can tell us.

Microsatellite instability cancer tests

New US research compares the data of newly diagnosed cancer patients who received two different types of tests to determine their course of treatment.

Novel genetic variants associated with Alzheimer’s disease

New research has identified several genetic variants that may influence Alzheimer’s disease risk, putting researchers one step closer to uncovering biological pathways to target for future treatment and prevention.

Bat swarming and immunity

Bats carry some of the deadliest zoonotic diseases that can infect both humans and animals, such as Ebola and COVID-19.

Fibroblast cells and pancreatic cancer growth

Older people may be at greater risk of developing pancreatic cancer and have poorer prognoses because of age-related changes in cells in the pancreas called fibroblasts, it is claimed.

Pores for thought

A team from Nottingham looks at intraoperative molecular diagnosis of brain tumours using nanopore sequencing.

Activating genes using CRISPR technology

There are over 7000 different rare genetic diseases, and often it can be a significant challenge and take a long time to receive a correct diagnosis.

The role of organelle repair in fighting infection

Research has found that cellular structures act as “molecular plasters” that protect against infections, such as tuberculosis. We talk to study co-author Claudio Bussi.

Early-stage stem cell therapy trial

An international team has shown that the injection of a type of stem cell into the brains of patients living with progressive multiple sclerosis (MS) is safe, well tolerated and has a long-lasting effect that appears to protect the brain from further damage.

How cancer cells use competition to evade the body’s defences

A Japanese team of scientists has examined the effects of the accumulation of stepwise gene mutations on cell competition and investigated its role in the cancer formation process.

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